• Target：
• Sck

• Fields：
• >>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>ErbB signaling pathway;>>Ras signaling pathway;>>Chemokine signaling pathway;>>Phospholipase D signaling pathway;>>VEGF signaling pathway;>>Focal adhesion;>>Natural killer cell mediated cytotoxicity;>>Neurotrophin signaling pathway;>>Insulin signaling pathway;>>Estrogen signaling pathway;>>Prolactin signaling pathway;>>Relaxin signaling pathway;>>Growth hormone synthesis, secretion and action;>>Alcoholism;>>Bacterial invasion of epithelial cells;>>Glioma;>>Chronic myeloid leukemia;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer

• Gene Name：
• SHC2

• Protein Name：
• SHC-transforming protein 2

• Human Gene Id：
• 25759

• Human Swiss Prot No：
• P98077

• Mouse Swiss Prot No：
• Q8BMC3

• Rat Gene Id：
• 314612

• Rat Swiss Prot No：
• O70142

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310

• Specificity：
• Sck Polyclonal Antibody detects endogenous levels of Sck protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SHC2;SCK;SHCB;SHC-transforming protein 2;Protein Sck;SHC-transforming protein B;Src homology 2 domain-containing-transforming protein C2;SH2 domain protein C2

• Observed Band(KD)：
• 59kD

• Background：
• domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,

• Function：
• domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,

• Subcellular Location：
• intracellular,cytosol,plasma membrane,

• Expression：
• Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

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