• Target：
• RGS12

• Gene Name：
• RGS12

• Protein Name：
• Regulator of G-protein signaling 12

• Human Gene Id：
• 6002

• Human Swiss Prot No：
• O14924

• Mouse Gene Id：
• 71729

• Mouse Swiss Prot No：
• Q8CGE9

• Rat Gene Id：
• 54292

• Rat Swiss Prot No：
• O08774

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human RGS12. AA range:141-190

• Specificity：
• RGS12 Polyclonal Antibody detects endogenous levels of RGS12 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RGS12;Regulator of G-protein signaling 12;RGS12

• Observed Band(KD)：
• 160kD

• Background：
• This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008],

• Function：
• function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 GoLoco domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PID domain.,similarity:Contains 1 RGS domain.,similarity:Contains 2 RBD (Ras-binding) domains.,tissue specificity:Isoform 3 is brain specific.,

• Subcellular Location：
• Nucleus . Cytoplasm . Cell projection, dendrite . Cell junction, synapse .; [Isoform 5]: Nucleus matrix . Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains. .

• Expression：
• Isoform 3 is brain specific.

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