• Target：
• RGS10

• Gene Name：
• RGS10

• Protein Name：
• Regulator of G-protein signaling 10

• Human Gene Id：
• 6001

• Human Swiss Prot No：
• O43665

• Mouse Gene Id：
• 67865

• Mouse Swiss Prot No：
• Q9CQE5

• Rat Swiss Prot No：
• P49806

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human RGS10. AA range:80-129

• Specificity：
• RGS10 Polyclonal Antibody detects endogenous levels of RGS10 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RGS10;Regulator of G-protein signaling 10;RGS10

• Observed Band(KD)：
• 20kD

• Background：
• Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• Function：
• function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.,PTM:Isoform 3 is phosphorylated on Ser-16.,similarity:Contains 1 RGS domain.,

• Subcellular Location：
• [Isoform 1]: Cytoplasm, cytosol . Nucleus . Forskolin treatment promotes phosphorylation and translocation to the nucleus. .; Nucleus .

• Expression：
• Uterus,

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