• Target：
• RASSF2

• Fields：
• >>Hippo signaling pathway - multiple species

• Gene Name：
• RASSF2

• Protein Name：
• Ras association domain-containing protein 2

• Human Gene Id：
• 9770

• Human Swiss Prot No：
• P50749

• Mouse Gene Id：
• 215653

• Mouse Swiss Prot No：
• Q8BMS9

• Rat Gene Id：
• 311437

• Rat Swiss Prot No：
• Q3B7D5

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human RASSF2. AA range:109-158

• Specificity：
• RASSF2 Polyclonal Antibody detects endogenous levels of RASSF2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RASSF2;KIAA0168;Ras association domain-containing protein 2

• Observed Band(KD)：
• 36kD

• Background：
• This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008],

• Function：
• function:Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,subunit:Interacts directly with activated KRAS in a GTP-dependent manner.,tissue specificity:Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.,

• Subcellular Location：
• Nucleus. Cytoplasm. Chromosome, centromere, kinetochore . Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.

• Expression：
• Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.

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