• Target：
• PSMD2

• Fields：
• >>Proteasome;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Epstein-Barr virus infection

• Gene Name：
• PSMD2

• Protein Name：
• 26S proteasome non-ATPase regulatory subunit 2

• Human Gene Id：
• 5708

• Human Swiss Prot No：
• Q13200

• Mouse Gene Id：
• 21762

• Mouse Swiss Prot No：
• Q8VDM4

• Rat Gene Id：
• 287984

• Rat Swiss Prot No：
• Q4FZT9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PSMD2. AA range:101-150

• Specificity：
• PSMD2 Polyclonal Antibody detects endogenous levels of PSMD2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PSMD2;TRAP2;26S proteasome non-ATPase regulatory subunit 2;26S proteasome regulatory subunit RPN1;26S proteasome regulatory subunit S2;26S proteasome subunit p97;Protein 55.11;Tumor necrosis factor type 1 receptor-associated protein

• Observed Band(KD)：
• 100kD

• Background：
• The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate

• Function：
• function:Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,function:Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.,similarity:Belongs to the proteasome subunit S2 family.,similarity:Contains 7 PC repeats.,tissue specificity:Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.,

• Subcellular Location：
• proteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle,proteasome regulatory particle, base subcomplex,membrane,proteasome accessory complex,proteasome storage granule,extracellular exosome,

• Expression：
• Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.

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