• Target：
• PKI β

• Gene Name：
• PKIB

• Protein Name：
• cAMP-dependent protein kinase inhibitor beta

• Human Gene Id：
• 5570

• Human Swiss Prot No：
• Q9C010

• Mouse Swiss Prot No：
• Q04758

• Rat Swiss Prot No：
• P27775

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human IPKB. AA range:29-78

• Specificity：
• PKI β Polyclonal Antibody detects endogenous levels of PKI β protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000,WB 1:500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PKIB;PRKACN2;cAMP-dependent protein kinase inhibitor beta;PKI-beta

• Molecular Weight(Da)：
• 8kD

• Background：
• protein kinase (cAMP-dependent, catalytic) inhibitor beta(PKIB) Homo sapiens This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012],

• Function：
• function:Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.,similarity:Belongs to the PKI family.,

• Subcellular Location：
• nucleus,cytoplasm,

• Expression：
• Placenta,

Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt. Reproductive Sciences Reprod Sci. 2021 Jan;28(1):178-185 IHC，WB Human 1:200，1:200 Placentas HTR8/SVneo cell

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