• Target：
• PHKG1

• Fields：
• >>Calcium signaling pathway;>>Insulin signaling pathway;>>Glucagon signaling pathway

• Gene Name：
• PHKG1

• Protein Name：
• Phosphorylase b kinase gamma catalytic chain skeletal muscle isoform

• Human Gene Id：
• 5260

• Human Swiss Prot No：
• Q16816

• Mouse Swiss Prot No：
• P07934

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PHKG1. AA range:241-290

• Specificity：
• PHKG1 Polyclonal Antibody detects endogenous levels of PHKG1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PHKG1;PHKG;Phosphorylase b kinase gamma catalytic chain; skeletal muscle isoform;Phosphorylase kinase subunit gamma-1

• Observed Band(KD)：
• 45kD

• Background：
• This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012],

• Function：
• catalytic activity:2 ATP + phosphorylase b = 2 ADP + phosphorylase a.,domain:The two calmodulin-binding domains appear to act in concert to bind a single molecule of calmodulin and are pseudosubstrate/autoinhibitory domains.,function:Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Polymer of 16 chains, four each of alpha, beta, gamma, and delta. Alpha and beta are regulatory chains, gamma is the catalytic chain, and delta is calmodulin.,

• Subcellular Location：
• cytosol,phosphorylase kinase complex,

• Expression：
• PCR rescued clones,Salivary gland,Skeletal muscle,

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