• Target：
• PDZK3

• Gene Name：
• PDZD2

• Protein Name：
• PDZ domain-containing protein 2

• Human Gene Id：
• 23037

• Human Swiss Prot No：
• O15018

• Rat Gene Id：
• 65034

• Rat Swiss Prot No：
• Q9QZR8

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PDZD2. AA range:51-100

• Specificity：
• PDZK3 Polyclonal Antibody detects endogenous levels of PDZK3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PDZD2;AIPC;KIAA0300;PDZK3;PDZ domain-containing protein 2;Activated in prostate cancer protein;PDZ domain-containing protein 3

• Molecular Weight(Da)：
• 302kD

• Background：
• The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015],

• Function：
• disease:May be associated with the early promotion of prostate tumoregenesis.,PTM:A secreted form is produced by caspase-mediated proteolytic cleavage.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 6 PDZ (DHR) domains.,subcellular location:At cell-cell contacts in lung epithelial cells.,subunit:Interacts with SCN10A, CTNND2 and PKP4.,tissue specificity:Expressed (at protein level) in prostate and many prostate tumors.,

• Subcellular Location：
• Nucleus . Cytoplasm . Endoplasmic reticulum . At cell-cell contacts in lung epithelial cells. .; [Processed PDZ domain-containing protein 2]: Secreted .

• Expression：
• Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.

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