• Target：
• PDGF-A

• Fields：
• >>EGFR tyrosine kinase inhibitor resistance;>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>Phospholipase D signaling pathway;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>Gap junction;>>JAK-STAT signaling pathway;>>Regulation of actin cytoskeleton;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>MicroRNAs in cancer;>>Glioma;>>Prostate cancer;>>Melanoma;>>Choline metabolism in cancer;>>Fluid shear stress and atherosclerosis

• Gene Name：
• PDGFA

• Protein Name：
• Platelet-derived growth factor subunit A

• Human Gene Id：
• 5154

• Human Swiss Prot No：
• P04085

• Mouse Gene Id：
• 18590

• Mouse Swiss Prot No：
• P20033

• Rat Gene Id：
• 25266

• Rat Swiss Prot No：
• P28576

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PDGF-A. AA range:105-154

• Specificity：
• PDGF-A Polyclonal Antibody detects endogenous levels of PDGF-A protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PDGFA;PDGF1;Platelet-derived growth factor subunit A;PDGF subunit A;PDGF-1;Platelet-derived growth factor A chain;Platelet-derived growth factor alpha polypeptide

• Observed Band(KD)：
• 17kD

• Background：
• platelet derived growth factor subunit A(PDGFA) Homo sapiens This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

• Function：
• domain:The long form contains a basic insert which acts as a cell retention signal.,function:Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.,miscellaneous:A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.,similarity:Belongs to the PDGF/VEGF growth factor family.,subunit:Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4.,

• Subcellular Location：
• Secreted. Released by platelets upon wounding.

• Expression：
• PCR rescued clones,

Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2019 Apr;112:108669 WB Mouse Primary murine lung fibroblasts (PMLFs)

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