• Target：
• PDE4C

• Fields：
• >>Purine metabolism;>>Metabolic pathways;>>cAMP signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Morphine addiction

• Gene Name：
• PDE4C

• Protein Name：
• cAMP-specific 3',5'-cyclic phosphodiesterase 4C

• Human Gene Id：
• 5143

• Human Swiss Prot No：
• Q08493

• Mouse Gene Id：
• 110385

• Mouse Swiss Prot No：
• Q3UEI1

• Rat Swiss Prot No：
• P14644

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PDE4C. AA range:291-340

• Specificity：
• PDE4C Polyclonal Antibody detects endogenous levels of PDE4C protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PDE4C;DPDE1;cAMP-specific 3';5'-cyclic phosphodiesterase 4C;DPDE1;PDE21

• Observed Band(KD)：
• 80kD

• Background：
• The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],

• Function：
• catalytic activity:Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.,enzyme regulation:Inhibited by rolipram.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,tissue specificity:Expressed in various tissues but not in cells of the immune system.,

• Subcellular Location：
• Cell projection, cilium .

• Expression：
• Expressed in various tissues but not in cells of the immune system.

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