NF-H Polyclonal Antibody

  • Catalog No.：YT3086
  • Applications：IHC;IF;ELISA
  • Reactivity：Human;Rat;Mouse;
    • Target：
    • NF-H
    • Fields：
    • >>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases
    • Gene Name：
    • NEFH
    • Protein Name：
    • Neurofilament heavy polypeptide
    • Human Gene Id：
    • 4744
    • Human Swiss Prot No：
    • P12036
    • Mouse Swiss Prot No：
    • P19246
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from human NF-H. AA range:923-972
    • Specificity：
    • NF-H Polyclonal Antibody detects endogenous levels of NF-H protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • NEFH;KIAA0845;NFH;Neurofilament heavy polypeptide;NF-H;200 kDa neurofilament protein;Neurofilament triplet H protein
    • Molecular Weight(Da)：
    • 112kD
    • Background：
    • Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008],
    • Function：
    • disease:Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.,function:Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.,online information:ALS genetic mutations db,polymorphism:The number of repeats is shown to vary between 29 and 30.,PTM:Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphor
    • Subcellular Location：
    • Cytoplasm, cytoskeleton . Cell projection, axon .
    • Expression：
    • Brain,Eye,Testis,

    Attributes

    • Code：
    • YT3086
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-22
    Order

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