• Target：
• NDUFS3

• Fields：
• >>Oxidative phosphorylation;>>Metabolic pathways;>>Thermogenesis;>>Retrograde endocannabinoid signaling;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy

• Gene Name：
• NDUFS3

• Protein Name：
• NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 mitochondrial

• Human Gene Id：
• 4722

• Human Swiss Prot No：
• O75489

• Mouse Gene Id：
• 68349

• Mouse Swiss Prot No：
• Q9DCT2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human NDUFS3. AA range:117-166

• Specificity：
• NDUFS3 Polyclonal Antibody detects endogenous levels of NDUFS3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• NDUFS3;NADH dehydrogenase [ubiquinone] iron-sulfur protein 3; mitochondrial;Complex I-30kD;CI-30kD;NADH-ubiquinone oxidoreductase 30 kDa subunit

• Observed Band(KD)：
• 40kD

• Background：
• This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009],

• Function：
• catalytic activity:NADH + acceptor = NAD(+) + reduced acceptor.,catalytic activity:NADH + ubiquinone = NAD(+) + ubiquinol.,function:Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.,similarity:Belongs to the complex I 30 kDa subunit family.,subunit:Mammalian complex I is composed of 45 different subunits.,

• Subcellular Location：
• Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .

• Expression：
• Brain,Cajal-Retzius cell,Pituitary,Skin,Stomach mucosa,Uter

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