• Target：
• SCN2B

• Gene Name：
• SCN2B

• Protein Name：
• Sodium channel subunit beta-2

• Human Gene Id：
• 6327

• Human Swiss Prot No：
• O60939

• Mouse Gene Id：
• 72821

• Mouse Swiss Prot No：
• Q56A07

• Rat Gene Id：
• 25349

• Rat Swiss Prot No：
• P54900

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SCN2B. AA range:71-120

• Specificity：
• Na+ CP type IIβ Polyclonal Antibody detects endogenous levels of Na+ CP type IIβ protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SCN2B;Sodium channel subunit beta-2

• Observed Band(KD)：
• 24kD

• Background：
• The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015],

• Function：
• function:Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR.,tissue specificity:Brain specific.,

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Brain specific.

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