• Target：
• Myosin VA

• Fields：
• >>Pathogenic Escherichia coli infection

• Gene Name：
• MYO5A

• Protein Name：
• Unconventional myosin-Va

• Human Gene Id：
• 4644

• Human Swiss Prot No：
• Q9Y4I1

• Mouse Gene Id：
• 17918

• Mouse Swiss Prot No：
• Q99104

• Rat Gene Id：
• 25017

• Rat Swiss Prot No：
• Q9QYF3

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MYO5A. AA range:1784-1833

• Specificity：
• Myosin VA Polyclonal Antibody detects endogenous levels of Myosin VA protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MYO5A;MYH12;Unconventional myosin-Va;Dilute myosin heavy chain; non-muscle;Myosin heavy chain 12;Myosin-12;Myoxin

• Observed Band(KD)：
• 220kD

• Background：
• This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008],

• Function：
• disease:Defects in MYO5A are a cause of Elejalde syndrome [MIM:256710]; also known as neuroectodermal melanolysosomal disease. Elejalde syndrome is an autosomal recessive condition characterized by skin hypopigmentation, the presence of large clumps of pigment in hair shafts, silvery-gray hair, accumulation of melanosomes in melanocytes and primary neurological abnormalities. Elejalde syndrome may be the same entity as Griscelli syndrome type I.,disease:Defects in MYO5A are a cause of Griscelli syndrome type-1 (GS1) [MIM:214450]; also known as Griscelli syndrome with primary neurologic impairment. Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, silvery-gray hair and accumulation of melanosomes in melanocytes. GS1 patients show developmental delay, hypotonia and ment

• Subcellular Location：
• ruffle,photoreceptor outer segment,cytoplasm,lysosome,early endosome,late endosome,peroxisome,endoplasmic reticulum,Golgi apparatus,cytosol,intermediate filament,actin filament,membrane,myosin complex,gr

• Expression：
• Detected in melanocytes.

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