• Target：
• Musculin

• Gene Name：
• MSC

• Protein Name：
• Musculin

• Human Gene Id：
• 9242

• Human Swiss Prot No：
• O60682

• Mouse Gene Id：
• 17681

• Mouse Swiss Prot No：
• O88940

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Musculin. AA range:131-180

• Specificity：
• Musculin Polyclonal Antibody detects endogenous levels of Musculin protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MSC;ABF1;BHLHA22;Musculin;Activated B-cell factor 1;ABF-1;Class A basic helix-loop-helix protein 22;bHLHa22

• Observed Band(KD)：
• 22kD

• Background：
• The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008],

• Function：
• function:Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer. Forms a heterodimer with TCF3.,tissue specificity:Expressed in lymphoid tissues, B-cell lines and activated B-cells.,

• Subcellular Location：
• Nucleus.

• Expression：
• Expressed in lymphoid tissues, B-cell lines and activated B-cells.

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