• Target：
• Moesin/Ezrin/Radixin

• Fields：
• >>Tight junction;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Measles;>>Proteoglycans in cancer

• Gene Name：
• MSN

• Protein Name：
• Moesin

• Human Gene Id：
• 4478/5962

• Human Swiss Prot No：
• P26038/P35241/P15311

• Mouse Gene Id：
• 17698/19684/22350

• Rat Gene Id：
• 81521/54319

• Rat Swiss Prot No：
• O35763/P31977

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Moesin/Ezrin/Radixin. AA range:524-573

• Specificity：
• Moesin/Ezrin/Radixin Polyclonal Antibody detects endogenous levels of Moesin/Ezrin/Radixin protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MSN;Moesin;Membrane-organizing extension spike protein;RDX;Radixin;EZR;VIL2;Ezrin;Cytovillin;Villin-2;p81

• Observed Band(KD)：
• 67kD

• Background：
• Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008],

• Function：
• function:Probably involved in connections of major cytoskeletal structures to the plasma membrane.,PTM:Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures.,similarity:Contains 1 FERM domain.,subcellular location:Phosphorylated form is enriched in microvilli-like structures at apical membrane.,subunit:In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1.,tissue specificity:In all tissues and cultured cells studied.,

• Subcellular Location：
• Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Apical cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, microvillus membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, microvillus . Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). Localizes at the uropods of T lymphoblasts. .

• Expression：
• In all tissues and cultured cells studied.

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