• Target：
• Melan-A

• Gene Name：
• MLANA

• Protein Name：
• Melanoma antigen recognized by T-cells 1

• Human Gene Id：
• 2315

• Human Swiss Prot No：
• Q16655

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MART-1. AA range:41-90

• Specificity：
• Melan-A Polyclonal Antibody detects endogenous levels of Melan-A protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MLANA;MART1;Melanoma antigen recognized by T-cells 1;MART-1;Antigen LB39-AA;Antigen SK29-AA;Protein Melan-A

• Observed Band(KD)：
• 15kD

• Background：
• tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,

• Function：
• tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,

• Subcellular Location：
• Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

• Expression：
• Expression is restricted to melanoma and melanocyte cell lines and retina.

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