MEL-1B-R Polyclonal Antibody
- Catalog No.:YT2727
- Applications:WB;IHC
- Reactivity:Human
- Target:
- MEL-1B-R
- Fields:
- >>Neuroactive ligand-receptor interaction;>>Circadian entrainment
- Gene Name:
- MTNR1B
- Protein Name:
- Melatonin receptor type 1B
- Human Gene Id:
- 4544
- Human Swiss Prot No:
- P49286
- Mouse Swiss Prot No:
- Q8CIQ6
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MTR1B. AA range:301-350
- Specificity:
- MEL-1B-R Polyclonal Antibody detects endogenous levels of MEL-1B-R protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000;IHC 1:50-300
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- MTNR1B;Melatonin receptor type 1B;Mel-1B-R;Mel1b receptor
- Observed Band(KD):
- 40kD
- Background:
- This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008],
- Function:
- function:High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.,online information:Melatonin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in retina and less in brain and hippocampus.,
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
- Expression:
- Expressed in retina and less in brain and hippocampus.
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- Antibody-FAQs
- Products Images
- Western Blot analysis of various cells using MEL-1B-R Polyclonal Antibody diluted at 1:1000
- Western Blot analysis of HepG2 cells using MEL-1B-R Polyclonal Antibody diluted at 1:1000
- Western blot analysis of lysates from 293, Jurkat, and HepG2 cells, using MTR1B Antibody. The lane on the right is blocked with the synthesized peptide.
- Western blot analysis of the lysates from HeLa cells using MTR1B antibody.
- Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).