• Target：
• M-cadherin

• Fields：
• >>Cell adhesion molecules

• Gene Name：
• CDH15

• Protein Name：
• Cadherin-15

• Human Gene Id：
• 1013

• Human Swiss Prot No：
• P55291

• Mouse Gene Id：
• 12555

• Mouse Swiss Prot No：
• P33146

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CDH15. AA range:81-130

• Specificity：
• M-cadherin Polyclonal Antibody detects endogenous levels of M-cadherin protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CDH15;CDH14;CDH3;Cadherin-15;Cadherin-14;Muscle cadherin;M-cadherin

• Observed Band(KD)：
• 89kD

• Background：
• This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008],

• Function：
• disease:A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).,disease:Defects in CDH15 are the cause of mental retardation autosomal dominant type 3 (MRD3) [MIM:612580]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.,similarity:Contains 5 cadherin domains.,tissue specificity:Expressed in the brai

• Subcellular Location：
• Cell membrane; Single-pass type I membrane protein.

• Expression：
• Expressed in the brain and cerebellum.

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