• Target：
• MC4-R

• Fields：
• >>Neuroactive ligand-receptor interaction

• Gene Name：
• MC4R

• Protein Name：
• Melanocortin receptor 4

• Human Gene Id：
• 4160

• Human Swiss Prot No：
• P32245

• Mouse Gene Id：
• 17202

• Mouse Swiss Prot No：
• P56450

• Rat Gene Id：
• 25635

• Rat Swiss Prot No：
• P70596

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MC4R. AA range:281-330

• Specificity：
• MC4-R Polyclonal Antibody detects endogenous levels of MC4-R protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MC4R;Melanocortin receptor 4;MC4-R

• Observed Band(KD)：
• 37kD

• Background：
• The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010],

• Function：
• disease:Defects in MC4R are a cause of autosomal dominant obesity [MIM:601665].,function:Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.,online information:Melanocortin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with ATRNL1.,tissue specificity:Brain, placental, and gut tissues.,

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein .

• Expression：
• Brain, placental, and gut tissues.

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