• Target：
• Mad 4

• Gene Name：
• MXD4

• Protein Name：
• Max dimerization protein 4

• Human Gene Id：
• 10608

• Human Swiss Prot No：
• Q14582

• Mouse Swiss Prot No：
• Q60948

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MAD4. AA range:10-59

• Specificity：
• Mad 4 Polyclonal Antibody detects endogenous levels of Mad 4 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MXD4;BHLHC12;MAD4;Max dimerization protein 4;Max dimerizer 4;Class C basic helix-loop-helix protein 12;bHLHc12;Max-associated protein 4;Max-interacting transcriptional repressor MAD4

• Molecular Weight(Da)：
• 24kD

• Background：
• This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008],

• Function：
• function:Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17.,

• Subcellular Location：
• Nucleus .

• Expression：
• Brain,Lung,Normal aorta,Spleen,

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