• Target：
• LTB4DH

• Gene Name：
• PTGR1

• Protein Name：
• Prostaglandin reductase 1

• Human Gene Id：
• 22949

• Human Swiss Prot No：
• Q14914

• Mouse Swiss Prot No：
• Q91YR9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PTGR1. AA range:75-124

• Specificity：
• LTB4DH Polyclonal Antibody detects endogenous levels of LTB4DH protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PTGR1;LTB4DH;Prostaglandin reductase 1;PRG-1;15-oxoprostaglandin 13-reductase;NADP-dependent leukotriene B4 12-hydroxydehydrogenase

• Observed Band(KD)：
• 36kD

• Background：
• This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009],

• Function：
• catalytic activity:11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.,catalytic activity:n-alkanal + NAD(P)(+) = alk-2-enal + NAD(P)H.,function:Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.,similarity:Belongs to the NADP-dependent oxidoreductase L4BD family.,subunit:Monomer or homodimer.,tissue specificity:High expression in the kidney, liver, and intestine but not in leukocytes.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• High expression in the kidney, liver, and intestine but not in leukocytes.

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