• Target：
• LPAAT-ε

• Fields：
• >>Glycerolipid metabolism;>>Glycerophospholipid metabolism;>>Metabolic pathways;>>Phospholipase D signaling pathway

• Gene Name：
• AGPAT5

• Protein Name：
• 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

• Human Gene Id：
• 55326

• Human Swiss Prot No：
• Q9NUQ2

• Mouse Swiss Prot No：
• Q9D1E8

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human AGPAT5. AA range:241-290

• Specificity：
• LPAAT-ε Polyclonal Antibody detects endogenous levels of LPAAT-ε protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• AGPAT5;1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon;1-acylglycerol-3-phosphate O-acyltransferase 5;1-AGP acyltransferase 5;1-AGPAT 5;Lysophosphatidic acid acyltransferase epsilon;LPAAT-epsilon

• Observed Band(KD)：
• 45kD

• Background：
• This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014],

• Function：
• catalytic activity:Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.,caution:It is uncertain whether Met-1 or Met-12 is the initiator.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,function:Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.,pathway:Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.,

• Subcellular Location：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein . Nucleus envelope . Mitochondrion .

• Expression：
• Widely expressed.

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