• Target：
• Latrophilin-2

• Gene Name：
• LPHN2

• Protein Name：
• Latrophilin-2

• Human Gene Id：
• 23266

• Human Swiss Prot No：
• O95490

• Mouse Swiss Prot No：
• Q8JZZ7

• Rat Gene Id：
• 171447

• Rat Swiss Prot No：
• O88923

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human LPHN2. AA range:551-600

• Specificity：
• Latrophilin-2 Polyclonal Antibody detects endogenous levels of Latrophilin-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• LPHN2;KIAA0786;LEC1;LPHH1;Latrophilin-2;Calcium-independent alpha-latrotoxin receptor 2;CIRL-2;Latrophilin homolog 1;Lectomedin-1

• Molecular Weight(Da)：
• 163kD

• Background：
• This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

• Function：
• function:Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 olfactomedin-like domain.,similarity:Contains 1 SUEL-type lectin domain.,subunit:Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85).,tissue specificity:Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly r

• Subcellular Location：
• Membrane ; Multi-pass membrane protein .

• Expression：
• Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.

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