• Target：
• KV4.1

• Gene Name：
• KCND1

• Protein Name：
• Potassium voltage-gated channel subfamily D member 1

• Human Gene Id：
• 3750

• Human Swiss Prot No：
• Q9NSA2

• Mouse Gene Id：
• 16506

• Mouse Swiss Prot No：
• Q03719

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human KCND1. AA range:558-607

• Specificity：
• KV4.1 Polyclonal Antibody detects endogenous levels of KV4.1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• KCND1;Potassium voltage-gated channel subfamily D member 1;Voltage-gated potassium channel subunit Kv4.1

• Observed Band(KD)：
• 70kD

• Background：
• This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013],

• Function：
• domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.,similarity:Belongs to the potassium channel family. D (Shal) subfamily.,subunit:Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with DPP10.,tissue specificity:Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.,

• Subcellular Location：
• Membrane; Multi-pass membrane protein. Cell projection, dendrite .

• Expression：
• Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.

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