• Target：
• KEPI

• Gene Name：
• PPP1R14C

• Protein Name：
• Protein phosphatase 1 regulatory subunit 14C

• Human Gene Id：
• 81706

• Human Swiss Prot No：
• Q8TAE6

• Mouse Gene Id：
• 76142

• Mouse Swiss Prot No：
• Q8R4S0

• Rat Gene Id：
• 171010

• Rat Swiss Prot No：
• Q8R4R9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PPP1R14C. AA range:51-100

• Specificity：
• KEPI Polyclonal Antibody detects endogenous levels of KEPI protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PPP1R14C;KEPI;Protein phosphatase 1 regulatory subunit 14C;Kinase-enhanced PP1 inhibitor;PKC-potentiated PP1 inhibitory protein;Serologically defined breast cancer antigen NY-BR-81

• Observed Band(KD)：
• 20kD

• Background：
• The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010],

• Function：
• function:Inhibitor of PPP1CA. Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.,similarity:Belongs to the PP1 inhibitor family.,tissue specificity:Detected in breast cancer.,

• Subcellular Location：
• Cytoplasm . Membrane ; Peripheral membrane protein .

• Expression：
• Detected in breast cancer.

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