• Target：
• JIK

• Fields：
• >>MAPK signaling pathway

• Gene Name：
• TAOK3

• Protein Name：
• Serine/threonine-protein kinase TAO3

• Human Gene Id：
• 51347

• Human Swiss Prot No：
• Q9H2K8

• Mouse Gene Id：
• 330177

• Mouse Swiss Prot No：
• Q8BYC6

• Rat Gene Id：
• 304530

• Rat Swiss Prot No：
• Q53UA7

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TAOK3. AA range:531-580

• Specificity：
• JIK Polyclonal Antibody detects endogenous levels of JIK protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TAOK3;DPK;JIK;KDS;MAP3K18;Serine/threonine-protein kinase TAO3;Cutaneous T-cell lymphoma-associated antigen HD-CL-09;CTCL-associated antigen HD-CL-09;Dendritic cell-derived protein kinase;JNK/SAPK-inhibitory kinase;Jun kinase-inhi

• Observed Band(KD)：
• 110kD

• Background：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Also localized to the peripheral cell membrane.,subunit:Self-associates.,tissue specificity:Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.,

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Also localized to the peripheral cell membrane.,subunit:Self-associates.,tissue specificity:Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.,

• Subcellular Location：
• Cytoplasm . Cell membrane ; Peripheral membrane protein . Also localized to the peripheral cell membrane.

• Expression：
• Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.

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