• Target：
• ITPK1

• Fields：
• >>Inositol phosphate metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system

• Gene Name：
• ITPK1

• Protein Name：
• Inositol-tetrakisphosphate 1-kinase

• Human Gene Id：
• 3705

• Human Swiss Prot No：
• Q13572

• Mouse Gene Id：
• 217837

• Mouse Swiss Prot No：
• Q8BYN3

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ITPK1. AA range:81-130

• Specificity：
• ITPK1 Polyclonal Antibody detects endogenous levels of ITPK1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ITPK1;Inositol-tetrakisphosphate 1-kinase;Inositol 1;3,4-trisphosphate 5/6-kinase;Inositol-triphosphate 5/6-kinase;Ins(1,3,4)P(3) 5/6-kinase

• Observed Band(KD)：
• 50kD

• Background：
• This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016],

• Function：
• catalytic activity:ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,catalytic activity:ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.,catalytic activity:ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.,caution:PubMed:11533064 detected some protein kinase activity and ability to phosphorylate transcription factors c-jun/JUN and ATF2. However, PubMed:15762844 showed that it does not have protein kinase activity.,cofactor:Binds 2 magnesium ions per subunit.,function:Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-

• Subcellular Location：
• intracellular,cytosol,apical plasma membrane,

• Expression：
• Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen.

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