• Target：
• IPMK

• Fields：
• >>Inositol phosphate metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system

• Gene Name：
• IPMK

• Protein Name：
• Inositol polyphosphate multikinase

• Human Gene Id：
• 253430

• Human Swiss Prot No：
• Q8NFU5

• Mouse Gene Id：
• 69718

• Mouse Swiss Prot No：
• Q7TT16

• Rat Gene Id：
• 171458

• Rat Swiss Prot No：
• Q99NI4

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human IPMK. AA range:311-360

• Specificity：
• IPMK Polyclonal Antibody detects endogenous levels of IPMK protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• IPMK;IMPK;Inositol polyphosphate multikinase;Inositol 1;3,4,6-tetrakisphosphate 5-kinase

• Observed Band(KD)：
• 47kD

• Background：
• This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010],

• Function：
• catalytic activity:ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.,catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate.,function:Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).,similarity:Belongs to the inositol phosphokinase (IPK) family.,tissue specificity:Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.,

• Subcellular Location：
• Nucleus .

• Expression：
• Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.

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