• Target：
• IP-10

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>Toll-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Hepatitis C;>>Influenza A;>>Epstein-Barr virus infection;>>Coronavirus disease - COVID-19

• Gene Name：
• CXCL10

• Protein Name：
• C-X-C motif chemokine 10

• Human Gene Id：
• 3627

• Human Swiss Prot No：
• P02778

• Mouse Swiss Prot No：
• P17515

• Immunogen：
• Synthesized peptide derived from IP-10 . at AA range: 20-100

• Specificity：
• IP-10 Polyclonal Antibody detects endogenous levels of IP-10 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CXCL10;INP10;SCYB10;C-X-C motif chemokine 10;10 kDa interferon gamma-induced protein;Gamma-IP10;IP-10;Small-inducible cytokine B10

• Molecular Weight(Da)：
• 11kD

• Background：
• C-X-C motif chemokine ligand 10(CXCL10) Homo sapiens This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014],

• Function：
• function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.,induction:By interferon gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the interferon gamma response.,mass spectrometry: PubMed:11559369,online information:CXCL10 entry,PTM:CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,

• Subcellular Location：
• Secreted .

• Expression：
• Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757).

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