• Target：
• IP Receptor

• Fields：
• >>Neuroactive ligand-receptor interaction;>>Vascular smooth muscle contraction;>>Platelet activation

• Gene Name：
• PTGIR

• Protein Name：
• Prostacyclin receptor

• Human Gene Id：
• 5739

• Human Swiss Prot No：
• P43119

• Mouse Swiss Prot No：
• P43252

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Prostacyclin Receptor. AA range:198-247

• Specificity：
• IP Receptor Polyclonal Antibody detects endogenous levels of IP Receptor protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PTGIR;PRIPR;Prostacyclin receptor;Prostaglandin I2 receptor;PGI receptor;PGI2 receptor;Prostanoid IP receptor

• Observed Band(KD)：
• 45kD

• Background：
• The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008],

• Function：
• function:Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.,PTM:Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.,PTM:Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.,similarity:Belongs to the G-protein coupled receptor 1 family.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Lung,Pancreas,Placenta,

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