• Target：
• Involucrin

• Gene Name：
• IVL

• Protein Name：
• Involucrin

• Human Gene Id：
• 3713

• Human Swiss Prot No：
• P07476

• Mouse Swiss Prot No：
• P48997

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Involucrin. AA range:536-585

• Specificity：
• Involucrin Polyclonal Antibody detects endogenous levels of Involucrin protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• IVL;Involucrin

• Observed Band(KD)：
• 68kD

• Background：
• involucrin(IVL) Homo sapiens Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008],

• Function：
• function:Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.,PTM:Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.,similarity:Belongs to the involucrin family.,subcellular location:Constituent of the scaffolding of the cornified envelope.,subunit:Directly or indirectly cross-linked to cornifelin (CNFN).,tissue specificity:Keratinocytes of epidermis and other stratified squamous epithelia.,

• Subcellular Location：
• Cytoplasm. Constituent of the scaffolding of the cornified envelope.

• Expression：
• Keratinocytes of epidermis and other stratified squamous epithelia.

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