• Target：
• IL-17Rα

• Fields：
• >>Cytokine-cytokine receptor interaction;>>IL-17 signaling pathway;>>Alcoholic liver disease

• Gene Name：
• IL17RA

• Protein Name：
• Interleukin-17 receptor A

• Human Gene Id：
• 23765

• Human Swiss Prot No：
• Q96F46

• Mouse Gene Id：
• 16172

• Mouse Swiss Prot No：
• Q60943

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human IL17RA. AA range:141-190

• Specificity：
• IL-17Rα Polyclonal Antibody detects endogenous levels of IL-17Rα protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• IL17RA;IL17R;Interleukin-17 receptor A;IL-17 receptor A;IL-17RA;CDw217;CD antigen CD217

• Observed Band(KD)：
• 90kD

• Background：
• Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014],

• Function：
• function:Receptor for IL17A. Binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.,PTM:Glycosylated.,tissue specificity:Widely expressed.,

• Subcellular Location：
• [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

• Expression：
• Widely expressed.

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