• Target：
• HDAC1

• Fields：
• >>Cell cycle;>>Longevity regulating pathway - multiple species;>>Notch signaling pathway;>>Neutrophil extracellular trap formation;>>Thyroid hormone signaling pathway;>>Huntington disease;>>Amphetamine addiction;>>Alcoholism;>>Human papillomavirus infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Viral carcinogenesis;>>MicroRNAs in cancer;>>Chronic myeloid leukemia

• Gene Name：
• HDAC1

• Protein Name：
• Histone deacetylase 1

• Human Gene Id：
• 3065

• Human Swiss Prot No：
• Q13547

• Mouse Gene Id：
• 433759

• Mouse Swiss Prot No：
• O09106

• Rat Gene Id：
• 297893

• Rat Swiss Prot No：
• Q4QQW4

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human HDAC1. AA range:387-436

• Specificity：
• HDAC1 Polyclonal Antibody detects endogenous levels of HDAC1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• HDAC1;RPD3L1;Histone deacetylase 1;HD1

• Observed Band(KD)：
• 55kD

• Background：
• Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.,PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates

• Subcellular Location：
• Nucleus .

• Expression：
• Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.

MiR-548an, Transcriptionally Downregulated by HIF1α/HDAC1, Suppresses Tumorigenesis of Pancreatic Cancer by Targeting Vimentin Expression. MOLECULAR CANCER THERAPEUTICS Mol Cancer Ther. 2016 Sep;15(9):2209-2219 WB Human 1:1000 BxPC-3 cell

Panobinostat reverses HepaCAM gene expression and suppresses proliferation by increasing histone acetylation in prostate cancer. GENE Gene. 2022 Jan;808:145977 WB Human LNCaP cell，DU145 cell

MiR-548an, transcriptionally downregulated by HIF-1α/HDAC1, suppresses tumorigenesis of pancreatic cancer by targeting vimentin expression." Molecular cancer therapeutics (2016): molcanther-0877.

A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis MOLECULAR CELL Kaiwen Bao WB,CoIP Human HeLa cell

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