• Target：
• Gα t2

• Fields：
• >>Phototransduction

• Gene Name：
• GNAT2

• Protein Name：
• Guanine nucleotide-binding protein G(t) subunit alpha-2

• Human Gene Id：
• 2780

• Human Swiss Prot No：
• P19087

• Mouse Gene Id：
• 14686

• Mouse Swiss Prot No：
• P50149

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GNAT2. AA range:1-50

• Specificity：
• Gα t2 Polyclonal Antibody detects endogenous levels of Gα t2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GNAT2;GNATC;Guanine nucleotide-binding protein G(t) subunit alpha-2;Transducin alpha-2 chain

• Observed Band(KD)：
• 40kD

• Background：
• Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in GNAT2 are the cause of achromatopsia type 4 (ACHM4) [MIM:139340]. Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination.,function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.,tissue specificity:Retinal rod outer segment.,

• Subcellular Location：
• Cell projection, cilium, photoreceptor outer segment . Photoreceptor inner segment . Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light. .

• Expression：
• Retinal rod outer segment.

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