• Target：
• GRK 5

• Fields：
• >>Chemokine signaling pathway;>>Endocytosis;>>Morphine addiction

• Gene Name：
• GRK5

• Protein Name：
• G protein-coupled receptor kinase 5

• Human Gene Id：
• 2869

• Human Swiss Prot No：
• P34947

• Mouse Gene Id：
• 14773

• Mouse Swiss Prot No：
• Q8VEB1

• Rat Gene Id：
• 59075

• Rat Swiss Prot No：
• Q62833

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GRK5. AA range:351-400

• Specificity：
• GRK 5 Polyclonal Antibody detects endogenous levels of GRK 5 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GRK5;GPRK5;G protein-coupled receptor kinase 5;G protein-coupled receptor kinase GRK5

• Observed Band(KD)：
• 68kD

• Background：
• This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Specifically phosphorylates the activated forms of G protein-coupled receptors.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney.,

• Subcellular Location：
• Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion.

• Expression：
• Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney.

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