• Target：
• GPR50

• Fields：
• >>Neuroactive ligand-receptor interaction

• Gene Name：
• GPR50

• Protein Name：
• Melatonin-related receptor

• Human Gene Id：
• 9248

• Human Swiss Prot No：
• Q13585

• Mouse Swiss Prot No：
• O88495

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MTR1L. AA range:301-350

• Specificity：
• GPR50 Polyclonal Antibody detects endogenous levels of GPR50 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GPR50;Melatonin-related receptor;G protein-coupled receptor 50;H9

• Observed Band(KD)：
• 68kD

• Background：
• This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010],

• Function：
• function:Does not bind melatonin.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Hypothalamus and pituitary.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Hypothalamus and pituitary.

Neuroprotective effect of acute melatonin treatment on hippocampal neurons against irradiation by inhibition of caspase‑3. Experimental and Therapeutic Medicine Exp Ther Med. 2016 Jun;11(6):2385-2390 IHC Rat hippocampi

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