• Target：
• GPR105

• Fields：
• >>Neuroactive ligand-receptor interaction

• Gene Name：
• P2RY14

• Protein Name：
• P2Y purinoceptor 14

• Human Gene Id：
• 9934

• Human Swiss Prot No：
• Q15391

• Mouse Gene Id：
• 140795

• Mouse Swiss Prot No：
• Q9ESG6

• Rat Gene Id：
• 171108

• Rat Swiss Prot No：
• O35881

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GPR105. AA range:146-195

• Specificity：
• GPR105 Polyclonal Antibody detects endogenous levels of GPR105 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• P2RY14;GPR105;KIAA0001;P2Y purinoceptor 14;P2Y14;G-protein coupled receptor 105;UDP-glucose receptor

• Observed Band(KD)：
• 39kD

• Background：
• The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008],

• Function：
• function:Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.

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