• Target：
• GM2/GD2 synthase

• Fields：
• >>Sphingolipid metabolism;>>Glycosphingolipid biosynthesis - ganglio series;>>Metabolic pathways

• Gene Name：
• B4GALNT1

• Protein Name：
• Beta-1,4 N-acetylgalactosaminyltransferase 1

• Human Gene Id：
• 2583

• Human Swiss Prot No：
• Q00973

• Mouse Gene Id：
• 14421

• Mouse Swiss Prot No：
• Q09200

• Rat Gene Id：
• 64828

• Rat Swiss Prot No：
• Q10468

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human B4GALNT1. AA range:281-330

• Specificity：
• GM2/GD2 synthase Polyclonal Antibody detects endogenous levels of GM2/GD2 synthase protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• B4GALNT1;GALGT;SIAT2;Beta-1;4 N-acetylgalactosaminyltransferase 1;(N-acetylneuraminyl)-galactosylglucosylceramide;GM2/GD2 synthase;GalNAc-T

• Observed Band(KD)：
• 60kD

• Background：
• beta-1,4-N-acetyl-galactosaminyltransferase 1(B4GALNT1) Homo sapiens GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013],

• Function：
• catalytic activity:UDP-N-acetyl-D-galactosamine + 1-O-(O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide = UDP + 1-O-(O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha-neuraminosyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide.,function:Involved in the biosynthesis of gangliosides GM2, GD2 and GA2.,online information:Beta-1,4 N-acetylgalactosaminyltransferase 1,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family.,subunit:Homodimer; disulfide-linked.,

• Subcellular Location：
• Golgi apparatus membrane ; Single-pass type II membrane protein .

• Expression：
• Brain,

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