• Target：
• GRID2

• Fields：
• >>Neuroactive ligand-receptor interaction;>>Long-term depression

• Gene Name：
• GRID2

• Protein Name：
• Glutamate receptor delta-2 subunit

• Human Gene Id：
• 2895

• Human Swiss Prot No：
• O43424

• Mouse Gene Id：
• 14804

• Mouse Swiss Prot No：
• Q61625

• Rat Gene Id：
• 79220

• Rat Swiss Prot No：
• Q63226

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GRID2. AA range:831-880

• Specificity：
• GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GRID2;GLURD2;Glutamate receptor delta-2 subunit;GluR delta-2 subunit

• Observed Band(KD)：
• 113kD

• Background：
• The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this

• Function：
• domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2.,

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein .

• Expression：
• Brain,Cerebellum,PCR rescued clones,

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