• Target：
• Glucosidase IIβ

• Fields：
• >>Protein processing in endoplasmic reticulum

• Gene Name：
• PRKCSH

• Protein Name：
• Glucosidase 2 subunit beta

• Human Gene Id：
• 5589

• Human Swiss Prot No：
• P14314

• Mouse Gene Id：
• 19089

• Mouse Swiss Prot No：
• O08795

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GLU2B. AA range:81-130

• Specificity：
• Glucosidase IIβ Polyclonal Antibody detects endogenous levels of Glucosidase IIβ protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PRKCSH;G19P1;Glucosidase 2 subunit beta;80K-H protein;Glucosidase II subunit beta;Protein kinase C substrate 60.1 kDa protein heavy chain;PKCSH

• Observed Band(KD)：
• 59kD

• Background：
• This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

• Function：
• disease:Defects in PRKCSH are a cause of polycystic liver disease (PCLD) [MIM:174050]. PCLD is an autosomal dominant disorder and is characterized by the presence of multiple liver cysts of biliary epithelial origin. PCLD is a distinct clinical and genetic entity that can occur independently from autosomal dominant polycystic kidney disease (ADPKD) [MIM:173900], which in a considerable but uncertain proportion of cases is associated with hepatic cysts.,function:Regulatory subunit of glucosidase II.,pathway:Glycan metabolism; N-glycan metabolism.,similarity:Contains 1 PRKCSH domain.,similarity:Contains 2 EF-hand domains.,subunit:Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH). Binds glycosylated PTPRC.,

• Subcellular Location：
• Endoplasmic reticulum .

• Expression：
• Lung,Lymphocyte,Platelet,

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