GLK Polyclonal Antibody
- Catalog No.:YT1915
- Applications:WB;ELISA
- Reactivity:Human;Mouse;Rat
- Target:
- GLK
- Fields:
- >>MAPK signaling pathway
- Gene Name:
- MAP4K3
- Protein Name:
- Mitogen-activated protein kinase kinase kinase kinase 3
- Human Gene Id:
- 8491
- Human Swiss Prot No:
- Q8IVH8
- Mouse Swiss Prot No:
- Q99JP0
- Rat Gene Id:
- 170920
- Rat Swiss Prot No:
- Q924I2
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MAP4K3. AA range:10-59
- Specificity:
- GLK Polyclonal Antibody detects endogenous levels of GLK protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- MAP4K3;RAB8IPL1;Mitogen-activated protein kinase kinase kinase kinase 3;Germinal center kinase-related protein kinase;GLK;MAPK/ERK kinase kinase kinase 3;MEK kinase kinase 3;MEKKK 3
- Observed Band(KD):
- 101kD
- Background:
- mitogen-activated protein kinase kinase kinase kinase 3(MAP4K3) Homo sapiens This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012],
- Function:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation.,tissue specificity:Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.,
- Subcellular Location:
- intracellular,cytoplasm,
- Expression:
- Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
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- Antibody-FAQs
- Products Images
- Western Blot analysis of various cells using GLK Polyclonal Antibody
- Western blot analysis of lysates from HepG2 and K562 cells, using MAP4K3 Antibody. The lane on the right is blocked with the synthesized peptide.