GFRα-4 Polyclonal Antibody

    • Catalog No.:YT1897
    • Applications:WB;ELISA
    • Reactivity:Human;Rat;Mouse;
      • Target:
      • GFRα-4
      • Gene Name:
      • GFRA4
      • Protein Name:
      • GDNF family receptor alpha-4
      • Human Swiss Prot No:
      • Q9GZZ7
      • Mouse Swiss Prot No:
      • Q9JJT2
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human GFRA4. AA range:141-190
      • Specificity:
      • GFRα-4 Polyclonal Antibody detects endogenous levels of GFRα-4 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • GFRA4;GDNF family receptor alpha-4;GDNF receptor alpha-4;GDNFR-alpha-4;GFR-alpha-4;Persephin receptor
      • Observed Band(KD):
      • 30kD
      • Background:
      • The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
      • Function:
      • alternative products:Additional isoforms seem to exist,function:Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.,similarity:Belongs to the GDNFR family.,tissue specificity:Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.,
      • Subcellular Location:
      • [Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.
      • Expression:
      • Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
      • Products Images
      • Western blot analysis of lysates from HeLa cells, using GFRA4 Antibody. The lane on the right is blocked with the synthesized peptide.