• Target：
• GFRα-4

• Gene Name：
• GFRA4

• Protein Name：
• GDNF family receptor alpha-4

• Human Gene Id：
• 64096

• Human Swiss Prot No：
• Q9GZZ7

• Mouse Swiss Prot No：
• Q9JJT2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GFRA4. AA range:141-190

• Specificity：
• GFRα-4 Polyclonal Antibody detects endogenous levels of GFRα-4 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GFRA4;GDNF family receptor alpha-4;GDNF receptor alpha-4;GDNFR-alpha-4;GFR-alpha-4;Persephin receptor

• Observed Band(KD)：
• 30kD

• Background：
• The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

• Function：
• alternative products:Additional isoforms seem to exist,function:Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.,similarity:Belongs to the GDNFR family.,tissue specificity:Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.,

• Subcellular Location：
• [Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.

• Expression：
• Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

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