• Target：
• GCS-β-1

• Fields：
• >>Purine metabolism;>>Metabolic pathways;>>cGMP-PKG signaling pathway;>>Vascular smooth muscle contraction;>>Gap junction;>>Platelet activation;>>Circadian entrainment;>>Long-term depression;>>Oxytocin signaling pathway;>>Renin secretion;>>Salivary secretion

• Gene Name：
• GUCY1B3

• Protein Name：
• Guanylate cyclase soluble subunit beta-1

• Human Gene Id：
• 2983

• Human Swiss Prot No：
• Q02153

• Mouse Gene Id：
• 54195

• Mouse Swiss Prot No：
• O54865

• Rat Gene Id：
• 25202

• Rat Swiss Prot No：
• P20595

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Guanylate Cyclase beta. AA range:10-59

• Specificity：
• GCS-β-1 Polyclonal Antibody detects endogenous levels of GCS-β-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GUCY1B3;GUC1B3;GUCSB3;GUCY1B1;Guanylate cyclase soluble subunit beta-1;GCS-beta-1;Guanylate cyclase soluble subunit beta-3;GCS-beta-3;Soluble guanylate cyclase small subunit

• Observed Band(KD)：
• 70kD

• Background：
• This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

• Function：
• catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,cofactor:Binds 1 or 2 heme groups per heterodimer.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• Detected in brain cortex and cerebellum (at protein level).

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