• Target：
• GCP4

• Gene Name：
• TUBGCP4

• Protein Name：
• Gamma-tubulin complex component 4

• Human Gene Id：
• 27229

• Human Swiss Prot No：
• Q9UGJ1

• Mouse Gene Id：
• 51885

• Mouse Swiss Prot No：
• Q9D4F8

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TUBGCP4. AA range:191-240

• Specificity：
• GCP4 Polyclonal Antibody detects endogenous levels of GCP4 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TUBGCP4;76P;GCP4;Gamma-tubulin complex component 4;GCP-4;hGCP4;Gamma-ring complex protein 76 kDa;h76p;hGrip76

• Observed Band(KD)：
• 76kD

• Background：
• This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015],

• Function：
• function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.,similarity:Belongs to the GCP family.,subunit:Gamma-tubulin complex is composed of gamma-tubulin, GCP2, GCP3, GCP4, GCP5 and GCP6.,tissue specificity:Ubiquitously expressed.,

• Subcellular Location：
• Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

• Expression：
• Ubiquitously expressed.

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