• Target：
• GABAA Rβ1

• Fields：
• >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>Serotonergic synapse;>>GABAergic synapse;>>Morphine addiction;>>Nicotine addiction

• Gene Name：
• GABRB1

• Protein Name：
• Gamma-aminobutyric acid receptor subunit beta-1

• Human Gene Id：
• 2560

• Human Swiss Prot No：
• P18505

• Mouse Gene Id：
• 14400

• Mouse Swiss Prot No：
• P50571

• Rat Gene Id：
• 25450

• Rat Swiss Prot No：
• P15431

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GABA-RB. AA range:401-450

• Specificity：
• GABAA Rβ1 Polyclonal Antibody detects endogenous levels of GABAA Rβ1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GABRB1;Gamma-aminobutyric acid receptor subunit beta-1;GABA(A) receptor subunit beta-1

• Observed Band(KD)：
• 55kD

• Background：
• The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008],

• Function：
• function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,

• Subcellular Location：
• Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .

• Expression：
• Brain,Epithelium,

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