GABAA Rα6 Polyclonal Antibody

    • Catalog No.:YT1823
    • Applications:WB;ELISA
    • Reactivity:Human;Mouse;Rat
      • Target:
      • GABAA Rα6
      • Fields:
      • >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Taste transduction;>>Morphine addiction;>>Nicotine addiction
      • Gene Name:
      • GABRA6
      • Protein Name:
      • Gamma-aminobutyric acid receptor subunit alpha-6
      • Human Gene Id:
      • 2559
      • Human Swiss Prot No:
      • Q16445
      • Mouse Swiss Prot No:
      • P16305
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human GABRA6. AA range:61-110
      • Specificity:
      • GABAA Rα6 Polyclonal Antibody detects endogenous levels of GABAA Rα6 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • GABRA6;Gamma-aminobutyric acid receptor subunit alpha-6;GABA(A) receptor subunit alpha-6
      • Observed Band(KD):
      • 51kD
      • Background:
      • GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008],
      • Function:
      • function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
      • Subcellular Location:
      • Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
      • Expression:
      • Cerebellum,
      • Products Images
      • Western Blot analysis of various cells using GABAA Rα6 Polyclonal Antibody diluted at 1:500
      • Western Blot analysis of MOUSE-BRAIN cells using GABAA Rα6 Polyclonal Antibody diluted at 1:500
      • Western blot analysis of lysates from HeLa and Jurkat cells, using GABRA6 Antibody. The lane on the right is blocked with the synthesized peptide.