• Target：
• GABA A Receptor α4

• Fields：
• >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Taste transduction;>>Morphine addiction;>>Nicotine addiction

• Gene Name：
• GABRA4

• Protein Name：
• Gamma-aminobutyric acid receptor subunit alpha-4

• Human Gene Id：
• 2557

• Human Swiss Prot No：
• P48169

• Mouse Gene Id：
• 14397

• Mouse Swiss Prot No：
• Q9D6F4

• Rat Gene Id：
• 140675

• Rat Swiss Prot No：
• P28471

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GABRA4. AA range:81-130

• Specificity：
• GABAA Rα4 Polyclonal Antibody detects endogenous levels of GABAA Rα4 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GABRA4;Gamma-aminobutyric acid receptor subunit alpha-4;GABA(A) receptor subunit alpha-4

• Observed Band(KD)：
• 60kD

• Background：
• Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],

• Function：
• function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,induction:The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,

• Subcellular Location：
• Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

• Expression：
• Brain,Brain cortex,

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