• Target：
• FRA1

• Fields：
• >>Wnt signaling pathway;>>Osteoclast differentiation;>>IL-17 signaling pathway;>>Human T-cell leukemia virus 1 infection

• Gene Name：
• FOSL1

• Protein Name：
• Fos-related antigen 1

• Human Gene Id：
• 8061

• Human Swiss Prot No：
• P15407

• Mouse Gene Id：
• 14283

• Mouse Swiss Prot No：
• P48755

• Rat Gene Id：
• 25445

• Rat Swiss Prot No：
• P10158

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Fra-1. AA range:101-150

• Specificity：
• Fra-1 Polyclonal Antibody detects endogenous levels of Fra-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• FOSL1;FRA1;Fos-related antigen 1;FRA-1

• Observed Band(KD)：
• 43kD

• Background：
• The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],

• Function：
• similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Fos subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer.,

• Subcellular Location：
• Nucleus .

• Expression：
• Blood,Endothelial cell,Kidney,Skin,

Fra‑1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro. INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2015 Apr;46(4):1677-1684 WB,IHC Human 1:100/1:300 Cervical cancer tissue

CD24 promotes the proliferation and inhibits the apoptosis of cervical cancer cells in vitro. ONCOLOGY REPORTS Oncol Rep. 2016 Mar;35(3):1593-1601 WB Human 1:300 cervical cancer tissues

Lipopolysaccharide Affects the Proliferation and Glucose Metabolism of Cervical Cancer Cells Through the FRA1/MDM2/p53 Pathway. International Journal of Medical Sciences Int J Med Sci. 2021; 18(4): 1030–1038 WB Human Hela cell, Caski cell

All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer. BIOTECHNOLOGY LETTERS Biotechnol Lett. 2020 Jun;42(6):1051-1060 WB Human 1:200 Hela cell, Caski cell

YWHAH activates the HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect the proliferation of gastric cancer cells. Yanhong Zhou WB Human 1:1000 SGC7901 GC cell,AGS GC cell

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