• Target：
• FLI1

• Fields：
• >>Transcriptional misregulation in cancer

• Gene Name：
• FLI1

• Protein Name：
• Friend leukemia integration 1 transcription factor

• Human Gene Id：
• 2313

• Human Swiss Prot No：
• Q01543

• Mouse Gene Id：
• 14247

• Mouse Swiss Prot No：
• P26323

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human FLI1. AA range:291-340

• Specificity：
• Fli-1 Polyclonal Antibody detects endogenous levels of Fli-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• FLI1;Friend leukemia integration 1 transcription factor;Proto-oncogene Fli-1;Transcription factor ERGB

• Observed Band(KD)：
• 50kD

• Background：
• This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

• Function：
• disease:A chromosomal aberration involving FLI1 is a cause of Ewing sarcoma [MIM:133450]. Translocation t(11;22)(q24;q12) with EWS.,function:Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.,miscellaneous:Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Can form homodimers or heterodimers with ETV6/TEL1.,

• Subcellular Location：
• Nucleus .

• Expression：
• Blood,Bone marrow,Lymph,Placenta,

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